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Histone Demethylase -
D-alpha-Hydroxyglutaric acid disodium salt
D-alpha-Hydroxyglutaric acid disodium salt
CAS No. 103404-90-6
D-alpha-Hydroxyglutaric acid disodium salt ( D-2-HG | D-2-hydroxyglutarate )
产品货号. M10168 CAS No. 103404-90-6
多种 α-KG 依赖性双加氧酶的竞争性抑制剂，包括组蛋白脱甲基酶和 5-甲基胞嘧啶 (5mC) 羟化酶的 TET 家族。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥381 | 有现货 |
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| 25MG | ￥543 | 有现货 |
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| 50MG | ￥907 | 有现货 |
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| 100MG | ￥1596 | 有现货 |
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| 200MG | ￥2373 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称D-alpha-Hydroxyglutaric acid disodium salt
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述多种 α-KG 依赖性双加氧酶的竞争性抑制剂，包括组蛋白脱甲基酶和 5-甲基胞嘧啶 (5mC) 羟化酶的 TET 家族。
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产品描述A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.
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体外实验——
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体内实验——
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同义词D-2-HG | D-2-hydroxyglutarate
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通路Chromatin/Epigenetic
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靶点Histone Demethylase
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受体α-KG
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研究领域Cancer
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适应症——
化学信息
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CAS Number103404-90-6
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分子量192.08
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分子式C5H6Na2O5
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纯度>98% (HPLC)
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溶解度H2O: ≥ 32 mg/mL
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SMILES[O-]C(CC[C@H](C([O-])=O)O)=O.[Na+].[Na+]
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化学全称Pentanedioic acid, 2-hydroxy-, disodium salt, (2R)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30.
2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
